Nephrotoxic Mechanisms of Drugs and Environmental ToxinsGeorge A. Porter Springer US, 31 okt 1982 - 466 pagina's The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem. |
Inhoudsopgave
Pathology of Acute Renal Failure | 11 |
Effect of Heavy Metals on Sodium Transport in Vitro | 25 |
Renal Hemodynamics in Nephrotoxic Acute Renal Failure | 37 |
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Nephrotoxic Mechanisms of Drugs and Environmental Toxins George A. Porter Gedeeltelijke weergave - 2013 |
Nephrotoxic Mechanisms of Drugs and Environmental Toxins George A. Porter Geen voorbeeld beschikbaar - 2012 |
Nephrotoxic Mechanisms of Drugs and Environmental Toxins George A. Porter Geen voorbeeld beschikbaar - 2013 |
Veelvoorkomende woorden en zinsdelen
activity acute renal failure administration agents alterations amino acids aminoglycosides amphotericin analgesic analgesic nephropathy animals antibiotics antibodies antigens APAP Biochem blood cadmium cellular cephaloglycin cephaloridine cephalosporins cephalothin CHCl3 chronic citrinin Clin clinical concentration cortex creatinine decrease deposits distal DMCTC dose Druet drug effect enzyme excretion experimental exposure Flamenbaum fluid gentamicin glomerular filtration rate glutathione heavy metal hemodynamics HgCl2 immune complex increased induced inhibition injection injury interstitial nephritis intracellular intrarenal ischemia ischemic kidney Kidney Int Kluwe lead nephropathy lesions liver lysosomal mechanism mercuric chloride metabolism metabolites metallothionein mg/kg mice mitochondria nephron nephrotoxicity nephrotoxins Nordberg normal observed patients Pharmacol phenacetin plasma potential pretreatment protein proteinuria proximal tubule rabbit reactions reactive renal cortical renal disease renal function renal tubular role serum creatinine sodium studies tetracyclines tissue tobramycin toxicity transport tubular cells tubular necrosis tubulointerstitial uptake uranyl nitrate urinary urine vitro
Verwijzingen naar dit boek
Cells, Membranes, and Disease: Including Renal E. Reid,G.M.W. Cooke,J.P. Luzio Fragmentweergave - 1987 |