Principles and Methods of Toxicology, Fifth EditionA. Wallace Hayes CRC Press, 25 sep 2007 - 2296 pagina's Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology. |
Inhoudsopgave
The History of Toxicology | 3 |
25 | 9 |
Raymond A Kemper Johnnie R Hayes and Matthew S Bogdanffy | 103 |
Toxicokinetics | 179 |
Kannan Krishnan and Melvin E Andersen | 231 |
in Predictive and Mechanistic Toxicology | 293 |
Michael A Dorato Carl L McMillian and Mary Jo Vodicnik | 325 |
8 | 342 |
28 | 1362 |
Inhalation Toxicology | 1407 |
29 | 1413 |
Detection and Evaluation of Chemically Induced Liver Injury | 1465 |
30 | 1473 |
Principles and Methods for Renal Toxicology | 1509 |
31 | 1520 |
Gastrointestinal Toxicology | 1541 |
Statistics for Toxicologists | 369 |
Rodricks David W Gaylor and Duncan Turnbull | 453 |
Dennis J Paustenbach and Amy K Madl | 475 |
Epidemiology for Toxicologists | 549 |
Principles of Pathology for Toxicology Studies | 591 |
The Information Infrastructure of Toxicology | 611 |
Foodborne Toxicants | 633 |
Solvents and Industrial Hygiene | 693 |
Mechanism of Action and Hazard Profiles | 727 |
Metals | 841 |
Ionizing Radiation | 897 |
Plant and Animal Toxins | 983 |
The Use of Laboratory Animals in Toxicology Research | 1055 |
Validation and Regulatory Acceptance of New Revised and Alternative Toxicological Methods 1 103 | 1103 |
Acute Toxicity and Eye Irritancy | 1131 |
Genetic Toxicology | 1179 |
ShortTerm Subchronic and Chronic Toxicology Studies | 1223 |
Principles of Testing for Carcinogenic Activity | 1265 |
26 | 1274 |
Principles of Clinical Pathology for Toxicology Studies | 1317 |
27 | 1354 |
Y James Kang | 1585 |
33 | 1593 |
Assessment of Male Reproductive Toxicity | 1605 |
34 | 1632 |
Mildred S Christian | 1641 |
Hormone Assays and Endocrine Function | 1713 |
36 | 1719 |
Effects of and Response to Drugs and Chemicals | 1755 |
37 | 1763 |
Assessment of Behavioral Toxicity | 1797 |
38 | 1844 |
39 | 1889 |
Organelles as Tools in Toxicology | 1923 |
40 | 1929 |
Analysis and Characterization of Enzymes and Nucleic Acids | 1973 |
Modern Instrumental Methods for Studying Mechanisms of Toxicology | 2041 |
Methods in Environmental Toxicology | 2113 |
Glossary | 2155 |
2193 | |
Overige edities - Alles bekijken
Veelvoorkomende woorden en zinsdelen
absorption acid activity Agency analysis animals Appl approach based pharmacokinetic bioavailability biological biomarkers blood body weight calculated carcinogens cell Chem chemical clearance clinical compound concentration conjugation contaminated cytochrome P450 dermal dioxin disease distribution dose dose-response dose-response relationship drug effects Environ enzyme Equation estimate evaluation example experimental expo exposure assessment extrapolation factors Figure gene glucuronidation glutathione glutathione S-transferase groups Health hormesis hormetic human IARC ical increase induced ingestion inhalation intake kinetics levels liver measured medicine ment metabolism metabolites metabonomics methods NOAEL organ oxidation parameters partition coefficients pathways PBPK model pesticide pharmacokinetic pharmacokinetic modeling Pharmacol physiologically based plasma poisons population potential predict protein proteomics rats regulatory response Risk Anal risk assessment rodent safety sample simulation soil specific statistical studies substrate Table tion tissue toxicity toxicogenomics toxicokinetic Toxicol toxicology tumor U.S. Environmental Protection uncertainty uptake variables vitro vivo xenobiotic
Verwijzingen naar dit boek
Casarett and Doull's Toxicology: The Basic Science of Poisons Louis J. Casarett,John Doull Geen voorbeeld beschikbaar - 2001 |