Nephrotoxicity in the Experimental and Clinical Situation: Part 1

acetaminophen activity acute renal failure angiotensin animals antibodies arterial atrial natriuretic factor autoradiography baboons binding Biochem Biol blood pressure Cancer carcinogenesis carcinogenic carcinoma cellular chemical chloroform Clin collecting ducts compounds concentration cortex cortical covalent cysteine cysteine conjugate Cytochem cytochrome P-450 decrease distal tubules dose drug effects electron microscope enzyme excretion experimental Figure fixation fluid gentamicin glomeruli glutathione HCBD hepatic Histochem histochemistry hormone hypertension increase induced inhibition inhibitor interstitial intracellular isolated perfused kidney Kidney Int lesions lipid liver mechanism medulla medullary membrane metabolism metabolites methods mice micropuncture microsomal monkeys nephron nephrotoxicity organic papillary necrosis Pathol perfused Pharmacol Physiol plasma produced prostaglandin protein proximal tubule rabbit kidney rat kidney reabsorption reactive renal cell renal function renal tubular renin renin-angiotensin renin-angiotensin system renomedullary role sections segments slices sodium specific specimen staining studies substrate techniques tion tissue toxicity Toxicol Toxicology transferase transport tumours urinary vitro vivo xenobiotic