Ivermectin and AbamectinSpringer New York, 10 jul 1989 - 363 pagina's Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications. |
Inhoudsopgave
Chemistry | 1 |
Isolation and Characterization | 24 |
Biosynthesis | 55 |
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abamectin Acaric activity acute toxicity administration adult aglycone animals anthelmintic application assay avermectin B₁a B₁ binding bioavailability body weight cattle centrifuge CH3 CH3 Chem chloride citrus clinical components compound concentration culture days after treatment degradation dermal Dictyocaulus Dirofilaria immitis dogs Dohme Research Laboratories dosage dose of ivermectin drug dung Dybas Ectoparasites effect of ivermectin Efficacy of ivermectin exposure feces fermentation Figure foliage GABA heartworm hexane infection ivermectin ivermectin treatment IVOMEC larvae lb ai/acre levels liver lungworms mectin Merck Sharp metabolism metabolites methanol mg/kg mg/kg/day mice microfilariae monosaccharide Mrozik mydriasis ND ND nematodes ng/ml Oesophagostomum oleandrose onchocerciasis parasites pesticide plasma production medium radioactivity reaction reduced reported safety samples sarcoptic seed medium sensitive Sharp & Dohme sheep soil species spider mite Streptomyces avermitilis strongyles studies subcutaneously swine Table Tests thrips tissue treated trials Trichostrongylus tube unpublished µg/kg