Handbook of Local Anesthesia - E-Book: Handbook of Local Anesthesia - E-BookElsevier Health Sciences, 21 mrt 2012 - 432 pagina's A practical, "how-to" guide to safe anesthesia practices in dentistry, Handbook of Local Anesthesia, 6th Edition covers all the latest advances in science, instrumentation, and pain control techniques. From basic concepts to specific injection techniques, from dosage charts to the proper care and handling of equipment, this book provides in-depth, full-color coverage of key anesthesia topics, including specific hazards and errors in technique that may result in complications. Written by Dr. Stanley Malamed, dentistry's leading expert on this subject, Handbook of Local Anesthesia is a valuable reference that will help you prevent, recognize, and manage complications of local anesthesia administration.
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... procaine, mepivacaine) prove to be relatively ineffective when applied topically to mucous membranes. To be effective as topical anesthetics, these drugs must be applied in concentrations that prove to be locally irritating to tissues ...
... procaine with an amide linkage replacing the ester linkage, is as potent a local anesthetic as procaine, yet because of its amide linkage, it is hydrolyzed much more slowly. Procaine is hydrolyzed in plasma in only a few minutes, but ...
... Procaine Lidocaine H7C3O C2H5 CH3 C3H7 H2N COOCH2CH2N NHCOCHN C2H5 CH 3 C2H5 C2H5 Propoxycaine Etidocaine H9C 4 CH 3 CH3 CH 3 N COOCH2CH2N NHCOCHN H CH3 CH 3 Tetracaine Mepivacaine CH 3 CH3 C4H9 COOCHCH2CHN NHCOCHN COOCH3 CH3 Cocaine ...
... Procaine 9.1 2 14-18 Procainamide 9.3 1 — pH 7.4 Extracellular RNH 750 + 250 RN Nerve sheath pH 7.4 Intracellular RNH+ RN RN 250 RNH+ 180 70 Figure 1-17. Mechanism of action of the local anesthetic molecule. Anesthetic pKa of 7.9 ...
... procaine, with a pKa of 9.1). The rate of onset of anesthetic action is related to the pKa of the local anesthetic (see Table 1-4). A local anesthetic with a lower pKa (<7.5) has a greater number of lipophilic free base molecules ...
Inhoudsopgave
II The Armamentarium | 76 |
III Techniques of Regional Anesthesia in Dentistry | 122 |
IV Complications Legal Considerations Questions and Future | 290 |
Index | 390 |
Inside back cover | 417 |