Ocular Blood Flow in GlaucomaRobert N. Weinreb, Alon Harris Kugler Publications, 2009 - 159 pagina's This is the sixth World Glaucoma Association Consensus. The relationship between ocular blood flow and glaucoma has been discussed for more than a century, and still it uniformly fuels debates at glaucoma meetings throughout the world. Clearly, the results of this report will have broad and significant impact on glaucoma research and clinical practice. The global faculty, consisting of leading authorities on the scientific and clinical aspects of ocular blood flow, have met in Fort Lauderdale on May 2, 2009 to discuss the reports and refine the consensus statements. |
Inhoudsopgave
| 3 | |
Anatomy of blood from the heart to the eye | 5 |
Overview of blood flow regulation in general | 7 |
The mediators of autoregulation | 8 |
The ocular vasculature and its role in regulating blood flow to the optic nerve and | 9 |
CLINICAL MEASUREMENT OF OCULAR BLOOD FLOW Alon Harris Ingrida Januleviciene Brent Siesky Leo Schmetterer Larry Kageman Ingeb... | 18 |
Color Doppler Imaging | 20 |
Laser Doppler Flowmetry and Scanning Laser Flowmetry | 23 |
What disease mechanisms lead to impaired blood flow in glaucoma? | 73 |
Systemic factors | 77 |
Vascular dysregulationperfusion instability | 90 |
What is the impact of medication and other modifiable factors on | 94 |
Systemic drugs | 100 |
Ocular surgery exercise | 103 |
Does modulation of blood flow alter glaucoma progression? | 104 |
4 Glaucoma and systemic vascular disease | 120 |
Retinal Vessel Analyzer | 25 |
Blue Field Entoptic Stimulation | 27 |
Laser Interferometric Measurement of Fundus Pulsation | 28 |
Dynamic Contour Tonometry and Ocular Pulse Amplitude | 30 |
Pulsatile Ocular Blood Flow POBF Analyzer | 31 |
Laser Speckle Method Laser Speckle Flowgraphy | 33 |
Digital Scanning Laser Ophthalmoscope Angiography | 35 |
Bidirectional Laser Doppler Velocimetry and Simultaneous Vessel | 37 |
Doppler Optical Coherence Tomography | 40 |
Retinal Oximetry | 42 |
CLINICAL RELEVANCE OF | 57 |
What is the evidence supporting a role for ocular blood flow | 60 |
Clinical evidence derived from different measurement parameters | 64 |
1C Evidence from experimental animal studies | 72 |
Systemic disease and glaucoma patients | 124 |
Cardiovascular diseases | 126 |
SHOULD MEASUREMENTS OF OCULAR BLOOD | 132 |
Interpreting clinical studies | 133 |
WHAT DO WE STILL NEED TO KNOW? Alon Harris Felipe Medeiros Rita Ehrlich Vital Costa Brent Siesky Ingrida Januleviciene Claude Burgoyne | 142 |
Ocular blood flow and visual function in glaucoma patients | 144 |
Ocular blood flow and optic nerve head structure | 145 |
The relationship between intraocular pressure and ocular blood flow | 147 |
The relationship between cerebrospinal fluid pressure and glaucoma | 148 |
Future research | 150 |
SUMMARY CONSENSUS POINTS | 154 |
INDEX OF AUTHORS | 160 |
Veelvoorkomende woorden en zinsdelen
Alon Harris angle glaucoma Araie Arch Clin Exp Arch Ophthalmol autoregulation betaxolol blood flow measurements blood flow velocity blood pressure blood velocity central retinal artery changes choroidal choroidal blood flow ciliary arteries Clin Exp Ophthalmol clinical color Doppler imaging correlated Curr Eye Res diastolic dorzolamide Effect of topical Eye Study Flammer flow in glaucoma Gherghel glaucoma patients Graefes Arch Clin hemodynamics increased intraocular pressure Invest Ophthalmol isometric exercise Jpn J Ophthalmol Kagemann laser speckle latanoprost mmHg nocturnal normal subjects normal tension glaucoma normal-tension glaucoma ocular blood flow ocular circulation ocular hypertension ocular perfusion pressure open-angle glaucoma ophthalmic artery Ophthalmol 1999 Ophthalmol 2002 Ophthalmol Vis Sci Ophthalmology optic nerve head POAG POBF posterior ciliary arteries primary open-angle glaucoma pulsatile ocular blood retinal blood flow retinal vessel diameter retrobulbar hemodynamics risk factor scanning laser Schmetterer significantly systemic blood pressure Tamaki timolol tissue