Enzyme Catalysis in Organic Synthesis, 3 Volume Set

Voorkant
Karlheinz Drauz, Harald Gröger, Oliver May
John Wiley & Sons, 26 mrt 2012 - 2038 pagina's
This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.
Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.
All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.
A must for all chemists and biotechnologists.
 

Geselecteerde pagina's

Inhoudsopgave

About the Editors
xli
Contents to Volume
1
Concepts in Biocatalysis
43
Discovery of Enzymes
67
Rational Design of Enzymes
89
Directed Evolution of Enzymes
119
Production and Isolation of Enzymes
191
Reaction and Process Engineering
217
References 107
998
Hydrolysis and Formation of PO Bonds
1001
Reductions
1035
Reduction of CC Double Bonds
1111
Reductive Amination of Keto Acids
1165
Contents to Volume 3
xxvii
Directed Evolution of Enzymes 119
xlii
Oxidations
1225

Hydrolysis and Formation of CO Bonds
249
Hydrolysis and Formation of Epoxides
363
Evolution
381
Hydrolysis and Formation of Glycosidic Bonds
417
Addition of Water to CC Bonds and its Elimination
467
Industrial Application and Processes Forming CO Bonds
503
CarbonOxygen Lyases
513
Contents to Volume 2
xxvii
Hydrolysis and Formation of CN Bonds
531
Hydrolysis of Nitriles to Carboxylic Acids
545
Hydrolysis of Amides
561
Hydrolysis and Formation of Hydantoins
651
Transformations 17
652
and its Application
665
17
675
Catalytic Mechanism
681
3
692
Peptide Synthesis
729
Application of Transaminases
779
Formation and Cleavage of CC Bonds
855
Cleavage and Formation of Cyanohydrins
947
Industrial Application and Processes Using CarbonCarbon Lyases
991
Oxidation of Alcohols Aldehydes and Acids
1325
1 2 23 872
1335
Specificity 717
1348
Transformations 17
1369
BaeyerVilliger Oxidations
1439
Aromatic Oxidations
1487
Oxidation of CN Bonds
1535
Oxidation at Sulfur and Oxidation of Amino Groups
1553
Organisms
1554
Halogenation
1569
Industrial Application and Processes Using Biocatalysts
1585
Industrial Application and Processes Using Isomerases
1685
Extended Applications of Enzyme Catalysis
1693
Catalytic Antibodies
1735
Chemoenzymatic Dynamic Kinetic Resolution and Related
1777
Biocatalysis in Material Science
1807
Industrial Applications of Enzymes in Emerging Areas
1837
Tabular Survey of Available Enzymes
1847
28
1917
29
1927
Index
1939
Copyright

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Over de auteur (2012)

Karlheiz Drauz is Vice President International Scientific Relations of Evonik. He evaluates interesting topics in research and development and networks globally with academic and industrial institutions. He did his Ph.D. at the Technical University Stuttgart, Germany, and started his career at Degussa 1980 in various positions in research and development. Amoungst his research interests are amino acids, peptides, biological active compounds, asymmetric synthesis, metal and biocatalysis as well as process chemistry. He holds about 160 patents, about 100 scientific publications. Since 1992 he is honorary professor for organic chemistry at the University Würzburg, Germany.

Harald Gröger is since 2006 Professor for organic chemistry at the University of Erlangen-Nürnberg, Germany. He studied chemistry at the Universities of Erlangen-Nürnberg and Oldenburg, before he did his postdoc with Masakatsu Shibasaki at the University of Tokyo. He worked from 1998 to 2006 in industry, e.g. as senior project manager for White Biotechnology of Degussa. He received several awards, like the Degussa innovation prize for new products (2003) and for new and optimized processes (2005), the Thieme award in 2007 and the German business sectors innovation prize (2004). His research interests are enzyme catalyzed organic synthesis, design and use of biomimetic chemocatalysts as well as sustainable chemistry.

Oliver May is Competence Manager Biocatalysis and responsible for coordinating biocatalysis related activities of DSM Pharmaceutical Products. Before joining DSM in April 2006, he was with Degussa (now Evonik) in various functions; latest as General Manager of Degussa's Service Center Biocatalysis. He was educated in Germany, receiving a PhD degree in Technical Biology from the University of Stuttgart where he worked at the Institute of Biochemical Engineering for Prof. C. Syldatk and at the German Center for Biotechnology in Braunschweig with Prof. D. Schomburg. He joined Caltech as a postdoc in 1998 where he worked until 2000 in the group of Prof. F.H. Arnold on directed evolution of enzymes. Oliver May has authored more than 30 scientific contributions in Journals and Books and more than 15 patent applications. He his team was awarded several innovation awards on hydantoinase technology, whole-cell processes and the latest on recombinant pig liver esterase in its application for production of a pharma intermediate.

Bibliografische gegevens