should book only to one of the frontier Stations between Italy and France, and there obtain a cheap circular ticket. These circular tickets are issued either to return to the same frontier Station as the starting point, or to commence at Modane and finish at Vintimille or vice versa, or to commence and end at any of the Italian frontier Stations of Switzerland or Austria. The following are the ordinary Single Journey Fares from London to Rome: Dieppe, Paris, Turin, Bologna, Florence Dover, Calais, Laon, St. Gothard Railway, Dover, Calais, Laon, St. Gothard Railway, Dover. Calais, Laon, Lucerne, Milan, Florence Dover. Calais, Paris, as above Harwich, Antwerp, Brussels, Metz, Bale, as Queenborough, Flushing. Brussels, Metz, etc. 17 ... 11 13 6 Dover. Calais, Laon, St. Gothard Railway, In order to relieve Delegates and their friends of all the trouble and inconvenience incidental to foreign travel Messrs. THOS. COOK AND SON have made arrangements to convey a 6360 a 8 12 7 9 8 18 3 6 12 9 7 10 ΙΟ 7 10 IO II 7 8 4 7 10 3036 3 96 17 17 17 10 15 10 7 13 9 3 Personally Conducted Party to Rome and back at a specially favourable and inclusive rate, providing for travelling tickets, hotel accommodation, consisting of bedroom, lights and service, and meat breakfast, transfer of passengers and baggage between Stations and Hotels, free conveyance of 56 lbs. of baggage, fees to hotel servants, waiters, porters, railway guards, etc., and the services of a competent Conductor, who will secure the railway and hotel accommodation in advance. The inclusive fare will be First Class, £16. 10s. od.* Second Class, £13. 10s. od.* If with full board (three meals a day), consisting of meat breakfast, dinner, and plain tea; or plain breakfast, luncheon, and dinner, 3. 7s. 6d. extra. *These rates apply to Delegates only. Fares for friends will be ITINERARY. Wednesday, September 20th.-The party will leave London, Victoria Station (L. C. & D. Railway) at 11 o'clock a.m., via Dover and Calais, for Paris. Arrive Paris 7.0 p.m. Hotel Accommodation provided at the Hotel London and New York, or Hotel St. Petersburg. Thursday, September 21st.-The day to be spent in Paris, leaving at 8.55 p.m. from the Lyons Station by Express Trains for Italy, via the Mt. Cenis tunnel. Friday, September 22nd.-Arrive Turin 2.0 p.m. The afternoon will be spent in Turin, affording an opportunity for visiting the celebrated Egyptian Museum and other places of interest. Hotel Trombetta. Saturday, September 23rd --Leave Turin 8.25 a.m. by Express Train via Genoa and Pisa, arriving Rome 11.15 p.m. Eight days will be spent in Rome. A special programme will be published, shewing the arrangements for visiting Naples, Vesuvius, Pompeii, etc. Hotel Allemagne, Rome. Monday, October 2nd.-Leave Rome 8.o a.m., arrive Pisa 2 22 p.m. Carriages to the Cathedral, Leaning Tower, and Baptistry, returning to the Station, leaving 3.20 p.m., arriving Genoa 10.30 pm. Tuesday, October 3rd.-Leave Genoa 30 p.m., arrive Turin 7.5 p.m. Leave 11.15 p.m. by Express for Paris, Wednesday, October 4th.—Arrive in Paris 5.34 p.m. Sleep in Paris. Thursday, October 5th.-Leave Paris (Nord Station) 11.30 a m. via Calais and Dover, arriving in London 7.20 p.m. Visitors may prolong their stay in Rome or Paris. EXTENSION.—Rome to Naples and back, including the ascent of Vesuvius-First Class, £2. 13s. 9d., Second Class, £2. 3s. 9d., Railway fares only. Members wishing to make a more extended tour may find the following itinerary, kindly worked out by Messrs. Cook, of service to them : : Via CALAIS, LAON, BALE, LUCERNE, MILAN, VENICE, FLORENCE. Wednesday, Sep. 13-Leave London 11.0 a.m. for Bale via Calais and Laon, arriving there at 6.5 a.m. Thursday, Sep. 14.-Leave next train and arrive Lucerne 9.10 a.m. Tuesday, 19.-Leave Milan at 12.55 noon, arrive Venice 6.35 p.m. Wednesday, 20, Thursday, 21.--In Venice. Friday, 22.-Leave Venice 10.5 a.m., arrive Florence at 6.27 p.m. Saturday, 23.-Leave Florence 11.35 p.m., arrive Rome 7.25 a m. on Sunday. Sunday, 24.-Till Monday, October 2nd, in Rome. Monday, Oct. 2,-Leave for Pisa at 80 a m., arriving Pisa 2.22 p.m. Leave 3.20 p.m. for Genoa, arriving 10.30 p.m. Sleep at Genoa. Tuesday, Oct. 3.-Leave Genoa 30 p.m., arrive Turin 7.5, leaving same evening 11.15 for Paris, arriving in Paris 5.34 p.m. on Wednesday. Sleep in Paris. Thursday, Oct. 5.- Leave Paris 11.30 am, arrive London 7.20 p.m. HOTELS IN ROME RECOMMENDED.-Hôtel d'Allemagne, Continental Hôtel, Hôtel Marini. It is recommended that rooms should be secured before-hand PUBLISHER'S DEPARTMENT. New Books, etc., Received. A Practical Treatise on Materia Medica and Therapeutics, with special Philadelphia and Selected Monographs on Dermatology. Translated for and published by the New Sydenham Society 1893. Lectures on Sanitary Law. By A. WYNTER BLYTH, M.R.C.S., L.S.A., Barrister-at-Law. London: Macmillan and Co. 1893. Domestic Medicine and Hygiene. By WILLIAM J RUSSELL, M.B. Third edition. London: W. H. Everett and Son. Hospital Sisters and their Duties. By E. C. E. Lückes. Matron to the London Hospital. Third edition. London The Scientific Press Limited. 1893. *** Authors can have reprints of articles at the following The re-arranging of the type is the principal cost in the production of these reprints, so that smaller numbers will be the same price. Larger numbers at a proportionate reduction. The Subscription (prepaid) to the Birmingham Medical Review is 6s. per annum, post free. NOTICE. -All Communications should be addressed to the Printers and Publishers, Messrs. Hall and English, 71, High Street, Birmingham. THE BIRMINGHAM MEDICAL REVIEW. AUGUST, 1893. ORIGINAL COMMUNICATIONS. REMARKS ON INFECTIOUS DISEASES BY EDWIN RICKARDS, M.B., F.R.C.P. Gentlemen, The choice of a subject for to-day's Inaugural Address caused me some anxiety, and the desire to say something which might stimulate useful thought, led me to ask your indulgence for making a somewhat new departure in addressing you at this our Annual Meeting on a strictly medical subject. The title of my address is, Remarks on Infectious Diseases with especial reference to their Treatment by Vaccines. I feel I ought to preface my remarks by giving an answer to a question which naturally suggests itself to all present-What is an Infectious Disease? The framing of a definition is always difficult, and it is especially so in this case, seeing that the class of infectious diseases is already an extensive one and its borders are being daily enlarged, so that a concise yet comprehensive definition which would answer for many members of the class would not fit all. With our present knowledge I think I am justified in defining an infectious disease as a disease caused by the presence in the body of a Pathogenic Micro-organism from *Presidential Address at the Annual Meeting of the Birmingham and Midland Counties Branch of the British Medical Association. E |