Cooperativity Theory in Biochemistry: Steady-State and Equilibrium SystemsSpringer Science & Business Media, 7 mrt 2013 - 460 pagina's During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a description of the frontiers of research where our knowledge is increasing steadily. |
Inhoudsopgave
3 | |
9 | |
Simple Equilibrium Binding | 34 |
The Model and the Monte Carlo Method | 40 |
Introduction to SteadyState Systems | 44 |
ThreeState SteadyState System | 56 |
SteadyState Systems without Explicit Interactions | 106 |
TwoConformation Complexes with Strong Interactions | 145 |
Small Systems or Complexes with Explicit Interactive | 164 |
Equilibrium Small Systems with Explicit Interactions | 176 |
SteadyState Small Systems with Explicit Interactions | 236 |
One or TwoDimensional Lattices of Units with Explicit | 318 |
OneDimensional Lattices of Interacting Units at Equilibrium | 362 |
SteadyState Monte Carlo Calculations with fα ƒß | 419 |
The BraggWilliams or MeanField Approximation | 432 |
456 | |
Overige edities - Alles bekijken
Cooperativity Theory in Biochemistry: Steady-State and Equilibrium Systems T.L. Hill Fragmentweergave - 1985 |
Cooperativity Theory in Biochemistry: Steady-State and Equilibrium Systems T.L. Hill Geen voorbeeld beschikbaar - 2011 |
Veelvoorkomende woorden en zinsdelen
A. V. Hill a₁ actin arbitrary binding constant bound ligand c₁ Ca² Ca2+ calculated Chapter complex concentration conformational change corresponding curve in Fig detailed balance dimer E₁ effect enzyme enzyme molecules equations equilibrium constant equivalent example explicit factor Figure fraction free energy grand partition function Hence Hill coefficient included independent interaction free energy interaction parameters intermolecular intersubunit interactions J₁ K₁ K₁c K₂ K₂c kinetic diagram L₁ lattice ligand ligand molecules linear membrane molecules Monte Carlo myosin N₁ N₂ nearest-neighbor notation one-way cycle p₁ P₂ pair phase transition positive cooperativity probability properties quasiequilibrium rate constants refers relative Section shown in Fig solution steady steady-state systems subsection subunits symmetry text for details trimer tropomyosin two-state cycle units unperturbed flux values y₁ α α αβ αι απ βι