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Pagina 46 - When a small quantity of it, either made into an ointment, or dissolved in alcohol, is rubbed for a minute or two upon the skin, a sensation of heat and prickling is experienced; to this, succeeds a feeling of numbness and constriction in the part, as if a heavy weight were laid upon it, or as if the skin were drawn together, by the powerful and involuntary contraction of the muscles beneath. This effect lasts from two or three, to twelve, or more hours, according to the quantity rubbed in.